Sedating and non sedating antihistamines

Glutamate is the major excitatory neurotransmitter at vestibular afferents (Serafin et al, 1992) as well as with neurons of the vestibular nuclei (where they may also release aspartate).

Glutamate interacts with several subreceptors including NMDA, AMPA, and KA, and metabotrophic receptors (Soto et al, 2013).

The term "vestibular suppressant" is a vague one generally used to indicate drugs that reduce nystagmus evoked by a vestibular imbalance or which reduce motion sickness.

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The H4 receptor affects primary vestibular neurons (Desmadryl et al, 2012).There are at least four major neurotransmitters of the vestibular system involved in the "three neuron arc" between the vestibular hair cells and oculomotor nuclei that drives the vestibulocular reflex.There are also a host of other neurotransmitters which modulate function.Acetylcholine (ACH) is both a peripheral and central agonist affecting muscarinic receptors, including the vestibular nucleus as well as efferent synapses (Soto et al, 2013).Receptors found in the pons and medulla, presumably those involved with dizziness, are almost exclusively of the M2 subtype (Barton et al, 1994).

Sedating and non sedating antihistamines